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Published on: March 4, 2014
MUNIX: Reproducibility and clinical correlations in Amyotrophic Lateral Sclerosis
Marcio Luiz Escorcio-Bezerra1, Agessandro Abrahao1, Isac de Castro2
1Department of Neurology, Universidade Federal de São Paulo, SP, Brazil.
Objective:
To study the reproducibility, diagnostic yield to detect denervation, and clinical correlations of the Motor Unit Number Index (MUNIX) in subjects with Amyotrophic Lateral Sclerosis (ALS).
Methods:
MUNIX evaluation was performed in three muscles twice on the same day to assess reproducibility. Cut-off values for the MUNIX were based on data from 51 healthy subjects (controls) to evaluate the sensitivity of the technique to detect denervation in 30 subjects with ALS.
Results:
The method had good reproducibility. The variability was greater in the ALS group. In 23 ALS subjects (77%), low MUNIX values were detected. Most of the muscles with low MUNIX had also low compound muscle action potential (CMAP) and strength, but these parameters were normal in 9% of muscles. According to ROC curve analysis, MUNIX was generally accurate (AUC=0.9504) for discriminating between healthy individuals and subjects with at least one denervated muscle.
Conclusions:
MUNIX variability was higher in the ALS group. The method showed good diagnostic performance for the detection of denervation in a sample of patients with ALS.
Significance:
This study demonstrated that in addition to being a quantitative tool MUNIX can detect denervation in subjects with ALS.
