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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Related Experiment Video

Updated: May 10, 2026

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
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The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

Published on: August 3, 2011

Screening for Skin Cancer: US Preventive Services Task Force Recommendation Statement.

, Kirsten Bibbins-Domingo1, David C Grossman2

  • 1University of California, San Francisco.

JAMA
|July 27, 2016
PubMed
Summary

Current evidence is insufficient to determine if visual skin exams by clinicians effectively screen for skin cancer in adults. More research is needed to balance potential benefits against harms like unnecessary biopsies and overdiagnosis.

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Last Updated: May 10, 2026

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
11:02

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

Published on: August 3, 2011

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Area of Science:

  • Dermatology
  • Preventive Medicine
  • Oncology

Background:

  • Melanoma has higher mortality rates than basal and squamous cell carcinoma.
  • In 2016, an estimated 76,400 US individuals developed melanoma, with 10,100 deaths.
  • The US Preventive Services Task Force (USPSTF) previously issued recommendations in 2009.

Purpose of the Study:

  • To provide an evidence-based update on the 2009 USPSTF recommendation regarding skin cancer screening.
  • To evaluate the effectiveness of clinical visual skin examinations in reducing skin cancer morbidity and mortality.

Main Methods:

  • Systematic review of evidence on visual skin examinations for skin cancer screening.
  • Assessment of screening effectiveness, potential harms, test characteristics, and early detection compared to usual care.
  • Inclusion of studies comparing primary care clinicians and dermatologists.

Main Results:

  • Limited direct evidence exists on the effectiveness of visual skin examinations for reducing melanoma morbidity and mortality.
  • Information regarding harms, such as unnecessary biopsies and overdiagnosis, is sparse but potential harms are recognized.
  • The quality of existing evidence, including a key ecologic study, has significant methodological limitations.

Conclusions:

  • The USPSTF concluded that current evidence is insufficient to assess the benefits and harms of clinician-performed visual skin examinations for skin cancer screening in adults.
  • An "I" statement indicates insufficient evidence to recommend for or against screening.
  • Further research is needed to clarify the net benefit of skin cancer screening.