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Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.4K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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[NEWS IN ETIOLOGY AND PATHOGENESIS OF IRRITATED BOWEL SYNDROME].

A A Sheptulin, M A Vize-Khripunova

    Klinicheskaia Meditsina
    |July 28, 2016
    PubMed
    Summary

    Irritable bowel syndrome (IBS) is more than just motility and sensitivity issues. New research suggests inflammation, gut permeability, and microflora changes are key factors in IBS development.

    Area of Science:

    • Gastroenterology
    • Immunology
    • Microbiome research

    Context:

    • Irritable bowel syndrome (IBS) is traditionally viewed as a functional gastrointestinal disorder.
    • Current understanding attributes IBS primarily to intestinal motility disturbances and visceral hypersensitivity.
    • This perspective often overlooks underlying pathophysiological mechanisms.

    Purpose:

    • To revise the conceptualization of irritable bowel syndrome.
    • To incorporate a broader range of etiological and pathogenetic factors into the understanding of IBS.
    • To highlight the multifactorial nature of IBS development.

    Summary:

    • The traditional concept of IBS as solely a disorder of motility and sensitivity requires reevaluation.
    • IBS development is influenced by factors including intestinal mucosal inflammation, altered permeability, prior infections, and dysbiosis.

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    A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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  • Genetic predisposition (gene polymorphism) and food hypersensitivity also play significant roles in IBS pathogenesis.

    • Impact:

    • This revised understanding facilitates a more comprehensive approach to IBS diagnosis and treatment.
    • It opens avenues for novel therapeutic strategies targeting inflammation, gut barrier function, and the microbiome.
    • Recognizing the multifactorial etiology can improve patient outcomes and quality of life for individuals with IBS.