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Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
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Opioids in Remote Ischemic Preconditioning-Induced Cardioprotection.

Puneet Kaur Randhawa1, Amteshwar Singh Jaggi1

  • 11 Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Patiala, Punjab, India.

Journal of Cardiovascular Pharmacology and Therapeutics
|July 28, 2016
PubMed
Summary

Remote ischemic preconditioning (RIPC) protects the heart by triggering the release of endogenous opioids. These opioids travel through the bloodstream to activate myocardial opioid receptors, offering cardioprotection.

Keywords:
cardioprotectionhumoralopioidsremote ischemic preconditioning

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Area of Science:

  • Cardiovascular Physiology
  • Neuroendocrinology

Background:

  • Remote ischemic preconditioning (RIPC) involves inducing brief ischemia in one body part to protect distant organs, notably the heart, from injury.
  • The endogenous opioid system, known for pain modulation, is also implicated in cardioprotective mechanisms.

Purpose of the Study:

  • To review the potential role of endogenous opioids in mediating the cardioprotective effects of RIPC.
  • To explore the mechanisms by which opioids contribute to heart protection during RIPC.

Main Methods:

  • Literature review of studies investigating RIPC and the endogenous opioid system.
  • Analysis of research on opioid release during RIPC and their interaction with myocardial opioid receptors.

Main Results:

  • Endogenous opioids, including endorphins, enkephalins, and dynorphins, are released during RIPC.
  • These opioids are critically involved in mediating RIPC-induced cardioprotection.
  • Opioids may be released into circulation and act on cardiac opioid receptors.

Conclusions:

  • Endogenous opioids play a significant role in the cardioprotective effects of RIPC.
  • Targeting the opioid system could be a therapeutic strategy for myocardial protection.