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Collagen and lipid biosynthesis in a case of epitheliogenesis imperfecta in cattle
J Frey1, A Chamson, J M Gourreau
1Laboratoire de Biochimie, Faculté de Médecine, Saint Etienne, France.
The Journal of Investigative Dermatology
|July 1, 1989
Abstract:
An analysis of the dermis and a study of collagen and lipid biosynthesis by fibroblast cultures were carried out in one case of epitheliogenesis imperfecta in a new born calf. This was found to be not only an epidermal disease with fissures and blisters within basal cells on the basement membrane but also a metabolic disease affecting the dermal fibroblasts. These fibroblasts showed a significant decrease in collagen biosynthesis with an increase in the percentage of type III collagen and also a decrease in the biosynthesis of lipids, especially glycerides and cholesterol.