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Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
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Mean arterial pressure change associated with cerebral blood flow in healthy older adults

Jeremy Deverdun1, Tasnime N Akbaraly2, Celine Charroud3

  • 1Laboratoire Charles Coulomb, CNRS UMR 5221, Université Montpellier II, Montpellier, France; Intrasense, Montpellier, Hérault, France; Department of Neuroradiology, Institut d'Imagerie Fonctionnelle Humaine, I2FH, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France; Institut de Génomique Fonctionnelle, UMR 5203, INSERM U661, Université Montpellier II, Université Montpellier I, France.

Neurobiology of Aging
|July 28, 2016
PubMed

Insights

Long-term changes in mean arterial pressure (MAP) significantly predict future cerebral blood flow (CBF) in older adults. This study highlights MAP changes as a key factor for brain health over time.

Area of Science:

  • Neuroscience
  • Cardiology
  • Gerontology

Background:

  • Cardiovascular risk factors are associated with brain health in aging.
  • Longitudinal data on cerebral blood flow (CBF) and cardiovascular risk factors are limited in healthy older adults.
  • Understanding these associations is crucial for maintaining cognitive function in later life.

Purpose of the Study:

  • To investigate the association between regional cerebral blood flow (CBF) and cardiovascular risk factors over a 12-year period.
  • To identify long-term predictors of CBF in healthy older adults.

Main Methods:

  • Prospective cohort study of healthy older adults (CRESCENDO study).
  • Cardiovascular risk factors measured over 12 years.
  • Gray matter CBF measured using arterial spin labeling MRI; analyzed with multivariate linear regression.

Main Results:

  • Increased mean arterial pressure (MAP) over 12 years correlated with lower CBF, unlike MAP at imaging.
  • High glycemia levels showed a trend towards association with lower CBF.
  • Women exhibited higher CBF than men; age, alcohol, smoking, BMI, CVD history, and hypertension were not associated with CBF.

Conclusions:

  • Long-term changes in MAP are a significant predictor of future CBF in older adults.
  • The dynamic changes in cardiovascular health, rather than static measures, are critical for brain perfusion.
  • Findings emphasize the importance of managing blood pressure trends for preserving cerebral blood flow in aging populations.

Keywords:
AgingArterial spin labellingCerebral blood flowHypertensionMagnetic resonance imaging

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