Related Experiment Video
Updated: Mar 17, 2026

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
Published on: September 6, 2019
Exclusive breastfeeding duration and infant infection
M A Quigley1, C Carson1, A Sacker2
1National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Exclusive breastfeeding (EBF) for less than 4 months or stopping by 6 months increases infant infection risk. Current guidelines of 4-6 months or 6 months EBF, with continued breastfeeding, are supported.
Area of Science:
- Pediatrics
- Public Health
- Epidemiology
Background:
- Exclusive breastfeeding (EBF) duration is a key factor in infant health.
- Understanding infection risks associated with varying EBF durations is crucial for public health policy.
- Previous research has indicated benefits of EBF, but specific risks related to duration require further investigation.
Purpose of the Study:
- To estimate the risk of infant infections (chest, diarrhoeal, ear) associated with different durations of exclusive breastfeeding (EBF).
- To compare infection risks between infants adhering to pre-2001 and post-2001 World Health Organization (WHO) breastfeeding policies.
Main Methods:
- Analysis of data from 15,809 term, singleton infants in the UK Millennium Cohort Study.
- Infants categorized by EBF duration: never, <2, 2-4, 4-6, and ≥6 months.
- Specific subgroup analysis for infants EBF for 4-6 months who introduced solids/formula before 6 months.
Main Results:
- EBF was not associated with ear infections.
- EBF for <4 months significantly increased the risk of chest infections and diarrhoea.
- Infants EBF for 4-6 months but stopping by 6 months showed an increased risk of chest infection and diarrhoea.
- No significant difference in infection risk between pre-2001 and post-2001 WHO policy groups.
Conclusions:
- Infants exclusively breastfed for less than 4 months or those stopping by 6 months face an elevated risk of infection.
- Findings support current WHO guidelines recommending EBF for 4-6 months or 6 months, followed by continued breastfeeding.
- Optimizing EBF duration is essential for reducing infant morbidity.
More Related Videos
05:04A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
Published on: September 22, 2023
13:00Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
Published on: July 31, 2021
Related Concept Videos
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Stages of Infection
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...