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Updated: Mar 17, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
An oral health optimized diet can reduce gingival and periodontal inflammation in humans - a randomized controlled
J P Woelber1, K Bremer2, K Vach3
1Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Medical Center - University of Freiburg, Hugstetter Str. 55, Freiburg, Germany. johan.woelber@uniklinik-freiburg.de.
Background:
The aim of this pilot study was to investigate the effects of four weeks of an oral health optimized diet on periodontal clinical parameters in a randomized controlled trial.
Methods:
The experimental group (n = 10) had to change to a diet low in carbohydrates, rich in Omega-3 fatty acids, and rich in vitamins C and D, antioxidants and fiber for four weeks. Participants of the control group (n = 5) did not change their dietary behavior. Plaque index, gingival bleeding, probing depths, and bleeding upon probing were assessed by a dentist with a pressure-sensitive periodontal probe. Measurements were performed after one and two weeks without a dietary change (baseline), followed by a two week transitional period, and finally performed weekly for four weeks.
Results:
Despite constant plaque values in both groups, all inflammatory parameters decreased in the experimental group to approximately half that of the baseline values (GI: 1.10 ± 0.51 to 0.54 ± 0.30; BOP: 53.57 to 24.17 %; PISA: 638 mm(2) to 284 mm(2)). This reduction was significantly different compared to that of the control group.
Conclusion:
A diet low in carbohydrates, rich in Omega-3 fatty acids, rich in vitamins C and D, and rich in fibers can significantly reduce gingival and periodontal inflammation.
Trial Registration:
German Clinical Trials Register; https://www.germanctr.de (DRKS00006301). Registered on 2015-02-21.
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