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Clinicophysiological outcomes after total pancreatectomy
Shuji Suzuki1,2, Junnosuke Miura3, Kyoko Shimizu4
1a Department of Gastroenterological Surgery , Tokyo Women's Medical University , Tokyo , Japan.
Scandinavian Journal of Gastroenterology
|July 28, 2016
Summary
Total pancreatectomy (TP) is feasible for pancreatic neoplasms. While some parameters temporarily decrease post-surgery, they normalize within 12 months with proper insulin and enzyme supplementation.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Endocrinology
Background:
- Total pancreatectomy (TP) is a high-risk procedure for pancreatic neoplasms.
- Advances in surgical techniques and postoperative care are increasing TP indications.
- Clinical outcomes following TP require thorough evaluation.
Purpose of the Study:
- To evaluate the clinical outcomes of patients who underwent total pancreatectomy (TP).
- To assess clinicophysiological changes up to 12 months after TP.
- To determine the feasibility of TP for pancreatic neoplasms.
Main Methods:
- Retrospective analysis of 41 patients who underwent TP between 2004 and 2011.
- Collection and analysis of pre- and postoperative clinicophysiological data up to 12 months.
- Statistical analysis to identify significant changes and influencing factors.
Main Results:
- Glycated hemoglobin (HbA1c), lymphocyte percentage, and hepatic Hounsfield unit levels showed significant changes post-TP.
- Most clinicophysiological parameters temporarily decreased but normalized by 12 months.
- Pancreatic enzyme dosage significantly impacted glycemic control (p < 0.05).
Conclusions:
- Total pancreatectomy is a viable surgical option for pancreatic neoplasms.
- Adequate synthetic insulin and pancreatic enzyme supplementation are crucial for successful outcomes.
- Clinicophysiological parameters generally normalize within a year after TP, indicating feasibility.
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