Related Experiment Video

Updated: Mar 17, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K

The role low microRNA-335 expression in prognosis prediction of human cancers

Du He1, Li Hong1, Wenjun Guo1

  • 1Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, P.R. China.

Journal of Cancer Research and Therapeutics
|July 28, 2016
PubMed
Abstract

Insights

The prognostic role of microRNA-335 (miR-335) in human cancers remains unclear. This meta-analysis suggests low miR-335 expression may impact overall survival, but more research is needed.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Research

Background:

  • MicroRNA-335 (miR-335) is implicated in human cancers.
  • Its precise prognostic significance as a biomarker is currently undetermined.

Purpose of the Study:

  • To investigate the prognostic role of miR-335 in human cancers.
  • To determine if miR-335 can serve as a reliable prognostic biomarker.

Main Methods:

  • A meta-analysis was conducted.
  • Eligible studies were identified from four major databases.
  • Inclusion/exclusion criteria were applied to select eight studies involving 1098 subjects.

Main Results:

  • miR-335 is deregulated in human cancer tissues compared to non-cancerous tissues.
  • Pooled hazard ratios indicated a potential association with overall survival (HR=1.35; 95% CI: 1.00–1.83).
  • The association with relapse-free survival was less conclusive (HR=1.54; 95% CI: 0.36–6.68).

Conclusions:

  • The current evidence is insufficient to definitively establish the prognostic value of low miR-335 expression.
  • Further clinical research is warranted to clarify the prognostic role of miR-335 in human cancers.

More Related Videos

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

25.1K
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

481

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.5K
MicroRNAs01:22

MicroRNAs

12.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K