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Expression of the complement system's activation factors in plasma of patients with early/late-onset severe

Yingdong He¹, Bingning Xu¹, Di Song^2,3,4

¹Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)

|July 28, 2016

Abstract

Problem:

To investigate the expression of complement activation factors in plasma of patients with early/late-onset severe pre-eclampsia.

Methods:

A case-control study was performed. The study group consisted of 30 cases of early-onset severe pre-eclampsia (EOSPE) and 30 cases of late-onset severe pre-eclampsia (LOSPE). Thirty cases were selected as the early-onset control group (E-control) and 30 as the late-onset control group (L-control). ELISA was used to test C1q, C4d, MBL, Bb, C3a, C5a, and MAC in the maternal peripheral circulation.

Results:

The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in EOSPE (all P<.01) and LOSPE (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.

Conclusion:

Abnormal activation of the complement system exists in the maternal circulation of patients with early- and late-onset severe pre-eclampsia. In patients complicated with LOSPE, the complement system was activated through both the classical and alternative pathways, while in EOSPE, the complement system was activated mainly through the alternative pathway.

Keywords:

alternative pathway complement activation pre-eclampsia

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