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Updated: Mar 17, 2026

Isolation of Murine Lymph Node Stromal Cells

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Peripheral tolerance can be modified by altering KLF2-regulated Treg migration.

Sudheer K Pabbisetty¹, Whitney Rabacal¹, Emmanuel J Volanakis²

¹Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;

Proceedings of the National Academy of Sciences of the United States of America

|July 28, 2016

Summary

Regulatory T cells (Tregs) are crucial for peripheral tolerance. Transcription factor KLF2 controls Treg migration to lymphoid organs, impacting autoimmunity and tolerance maintenance.

Keywords:

KLF2 Treg migration autoimmunity peripheral tolerance regulatory T cell

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Last Updated: Mar 17, 2026

Isolation of Murine Lymph Node Stromal Cells

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

Area of Science:

Immunology
Cell Biology

Background:

Regulatory T cells (Tregs) are vital for maintaining peripheral tolerance.
Understanding Treg function is key for developing therapies for autoimmunity and cancer.

Purpose of the Study:

To investigate the role of transcription factor Kruppel-like factor 2 (KLF2) in naive Treg migration.
To determine how KLF2-mediated Treg trafficking impacts peripheral tolerance and autoimmunity.

Main Methods:

Analysis of KLF2-deficient Tregs and their migration patterns.
Assessment of Treg homing receptor regulation by KLF2.
Correlation of Treg recruitment to secondary lymphoid organs (SLOs) with disease severity and tolerance.

Main Results:

KLF2 deficiency impairs naive Treg migration to SLOs.
Reduced Treg trafficking to SLOs is sufficient to induce autoimmunity.
Modulating KLF2 levels affects Treg distribution, influencing peripheral tolerance.

Conclusions:

KLF2 is a critical regulator of Treg migration to SLOs, essential for maintaining peripheral tolerance.
Targeting KLF2-mediated Treg trafficking offers a potential strategy to enhance tolerance or treat autoimmune diseases.