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Spatial selective manipulation of microbubbles by tunable surface acoustic waves.

Wei Zhou¹, Lili Niu¹, Feiyan Cai¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055, People's Republic of China.

Biomicrofluidics

|July 28, 2016

Summary

This study introduces a microfluidic device using surface acoustic waves (SAWs) for precise microbubble (MB) manipulation. The device allows for selective, flexible, and two-dimensional control of MBs, advancing microfluidic applications.

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Area of Science:

Microfluidics
Acoustic manipulation
Biomedical engineering

Background:

Microbubbles (MBs) are crucial in various applications, including drug delivery and diagnostics.
Precise manipulation of MBs is essential for controlling these applications.
Existing methods for MB manipulation often lack flexibility and selectivity.

Purpose of the Study:

To develop a microfluidic device for selective and flexible manipulation of microbubbles (MBs).
To utilize surface acoustic waves (SAWs) generated by slant-finger interdigital transducers (SFITs) for MB control.
To achieve precise, two-dimensional manipulation of MBs.

Main Methods:

Fabrication of a microfluidic device incorporating a pair of SFITs.
Generation of SAWs by applying excitation signals to SFITs.
Selective control of MBs by adjusting the frequency and phase of the excitation signal.

Main Results:

MBs were selectively manipulated along the acoustic aperture by adjusting SAW frequency.
A linear relationship was observed between MB displacement and frequency shift.
A transportation resolution of 15.19 ± 2.65 μm was achieved with a 10 kHz frequency step.
Two-dimensional MB manipulation was demonstrated by combining frequency and phase variations.

Conclusions:

The developed microfluidic device offers precise and flexible control over MBs using SAWs.
This technology enables selective manipulation of MBs in one and two dimensions.
The findings present a simple yet effective method for advancing microfluidic applications involving MBs.