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3 beta-O-palmityl longispinogenin from Trichocereus chilensis
1Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
Journal of Natural Products
|March 1, 1989
Summary
A new fatty acid ester, 3 beta-O-palmityl longispinogenin, was isolated from Trichocereus chilensis aerial parts. This compound demonstrated no significant activity in brine shrimp lethality or cytotoxicity bioassays.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Pharmacognosy
Background:
- Trichocereus chilensis is a cactus species with potential for novel compound discovery.
- Triterpenoids are a diverse class of natural products with various biological activities.
Purpose of the Study:
- To isolate and characterize new chemical constituents from the aerial parts of Trichocereus chilensis.
- To evaluate the potential biological activity of the isolated compounds.
Main Methods:
- Aerial parts of Trichocereus chilensis were extracted.
- Chemical and spectroscopic methods (e.g., NMR, MS) were employed for structure elucidation.
- Bioassays including brine shrimp lethality and cytotoxicity assays were performed.
Main Results:
- A novel triterpenetriol fatty acid ester, identified as 3 beta-O-palmityl longispinogenin (olean-12-ene-3 beta,16 beta,28-triol-3-palmitate), was isolated and characterized.
- The isolated compound (Compound 1) showed no significant lethality in brine shrimp bioassays.
- Compound 1 exhibited no cytotoxicity in the tested bioassays.
Conclusions:
- The chemical investigation of Trichocereus chilensis led to the discovery of a new triterpenoid ester.
- 3 beta-O-palmityl longispinogenin does not possess significant cytotoxic or lethality-inducing properties based on the conducted assays.