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Auditory evoked potential P300 in adults: reference values.

Dayane Domeneghini Didoné1, Michele Vargas Garcia1, Sheila Jacques Oppitz1

  • 1Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.

Einstein (Sao Paulo, Brazil)
|July 28, 2016
PubMed
Summary
This summary is machine-generated.

This study establishes reference intervals for cognitive potential P300 latency in adults. The maximum acceptable P300 latency was determined to be 362.5ms for individuals aged 18-59.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Auditory Evoked Potentials

Background:

  • The P300 event-related potential is a valuable neurophysiological marker.
  • Establishing normative data for P300 latency is crucial for clinical interpretation.
  • Tone burst stimuli offer a controlled method for auditory assessment.

Purpose of the Study:

  • To determine reference intervals for P300 latency.
  • To utilize tone burst stimuli for cognitive potential assessment.
  • To provide normative data for adults aged 18-59 years.

Main Methods:

  • Twenty-eight participants (18-59 years) were included.
  • P300 recordings utilized a two-channel Masbe device with standard electrode placement (Fpz, Cz, M1, M2).
  • Binaural tone burst stimuli (80 dB HL, 1000Hz frequent, 2000Hz rare) were employed.

Main Results:

  • The mean age of participants was 35 years.
  • The average P300 latency observed was 305ms.
  • The standard deviation for P300 latency was 28.75ms.

Conclusions:

  • A maximum acceptable P300 latency of 362.5ms was established for adults (18-59 years).
  • This reference interval is based on the described tone burst stimulus protocol.
  • These findings contribute to the standardization of P300 latency assessment.