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Related Experiment Video

Updated: Mar 17, 2026

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus
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Cost Analysis of Universal Screening vs. Risk Factor-Based Screening for Methicillin-Resistant Staphylococcus aureus

Virginia R Roth1,2,3, Tara Longpre3, Doug Coyle3,4

  • 1Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.

Plos One
|July 28, 2016
PubMed
Summary

Universal MRSA screening is costly and not clinically effective for reducing transmission. Risk factor-based screening is a more economical approach for hospitals managing MRSA.

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Area of Science:

  • Infectious Disease Epidemiology
  • Health Economics
  • Clinical Microbiology

Background:

  • Conflicting literature exists on optimal Methicillin-resistant Staphylococcus aureus (MRSA) screening strategies.
  • Nosocomial MRSA transmission remains a significant healthcare challenge.

Purpose of the Study:

  • To assess and compare the costs of universal versus risk factor-based MRSA screening.
  • To evaluate the economic impact of different MRSA screening protocols on hospital resources.

Main Methods:

  • A comparative cost analysis was performed at a large tertiary care facility.
  • Data from risk factor-based screening (2006-2007) and universal screening (2008-2009) were analyzed.
  • A model incorporated PCR testing probabilities, MRSA bacteremia rates, and associated healthcare costs.

Main Results:

  • Risk factor-based screening cost over $780,000 annually, covering ~30% of patients.
  • Universal screening cost over $1.94 million annually, covering ~83% of patients, an excess of $1.16 million/year.
  • The estimated additional cost per patient screened under universal screening was $17.76.

Conclusions:

  • Universal MRSA screening is a significant financial burden on hospitals.
  • Universal screening has not been proven effective in reducing MRSA transmission.
  • Findings can inform future economic analyses of MRSA interventions.