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HIV-Related Lymphoblastic Lymphoma
M Serke1, S Serke1, B Geiseler1
1a Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Abteilung für Innere Medizin mit Schwerpunkt Hämatologie/Onkologie, Berlin, FRG, 19.
Leukemia & Lymphoma
|July 28, 2016
Summary
This study reviewed 17 HIV-associated lymphomas, finding high response rates to chemotherapy but common relapses. An optimal treatment regimen for these aggressive lymphomas remains elusive.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- HIV-associated lymphomas are aggressive malignancies.
- Burkitt-type lymphomas are common in HIV-infected individuals.
- Chemotherapy is a primary treatment modality.
Purpose of the Study:
- To review clinical records of patients with HIV-associated lymphomas.
- To evaluate treatment response and survival rates.
- To assess the effectiveness of current therapeutic regimens.
Main Methods:
- Retrospective review of 17 patients with HIV-associated lymphomas (diagnosed 1/85-1/90).
- Histological and immunohistochemical/cytological and immunocytochemical analyses were performed.
- Patients were staged using Ann Arbor and CDC criteria.
Main Results:
- 81% overall response rate to chemotherapy (CR + PR), with 53% achieving complete remission (CR).
- High incidence of relapses shortly after achieving CR.
- Extranodal involvement common, particularly gastrointestinal tract and bone marrow.
- Median survival post-relapse was approximately 5 months.
Conclusions:
- Current chemotherapy regimens yield high initial response rates for HIV-associated lymphomas.
- Frequent relapses indicate the need for improved therapeutic strategies.
- An optimal treatment regimen for these aggressive lymphomas has not yet been established.
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