Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

1.4K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.4K
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.0K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.0K
Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

238
Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
238
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

116
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
116
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

102
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
102
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.4K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment for calcium channel blocker poisoning: a systematic review.

Clinical toxicology (Philadelphia, Pa.)·2014
Same author

Extracorporeal treatment for acetaminophen poisoning: recommendations from the EXTRIP workgroup.

Clinical toxicology (Philadelphia, Pa.)·2014
Same author

An Internet snapshot study to compare the international availability of the novel psychoactive substance methiopropamine.

Clinical toxicology (Philadelphia, Pa.)·2014
Same author

Four-hour acetaminophen concentration estimation after ingested dose based on pharmacokinetic models.

Clinical toxicology (Philadelphia, Pa.)·2014
Same author

Treating acetaminophen overdose: thresholds, costs and uncertainties.

Clinical toxicology (Philadelphia, Pa.)·2013
Same author

Acceptor hydroxyl group mapping for human milk alpha 1-3 and alpha 1-3/4 fucosyltransferases.

Bioorganic & medicinal chemistry·1996

Related Experiment Video

Updated: Mar 17, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.8K

Double-peaked Acetaminophen Concentration Secondary to Intestinal Trauma.

B Alyahya, S Tamur, S Aljenedil

    Journal of Population Therapeutics and Clinical Pharmacology = Journal De La Therapeutique Des Populations Et De La Pharmacologie Clinique
    |July 28, 2016
    PubMed
    Summary

    Delayed gastrointestinal absorption significantly alters acetaminophen toxicokinetics. Reduced motility from trauma or surgery impacts treatment duration and monitoring of acetaminophen levels.

    More Related Videos

    Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
    06:35

    Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

    Published on: June 28, 2021

    4.6K
    Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
    06:05

    Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

    Published on: January 27, 2023

    29.3K

    Related Experiment Videos

    Last Updated: Mar 17, 2026

    An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
    08:59

    An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

    Published on: December 3, 2020

    8.8K
    Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
    06:35

    Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

    Published on: June 28, 2021

    4.6K
    Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
    06:05

    Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

    Published on: January 27, 2023

    29.3K

    Area of Science:

    • Toxicology
    • Gastroenterology

    Background:

    • Reduced gastrointestinal motility can alter drug absorption and elimination.
    • Acetaminophen (APAP) overdose management relies on timely toxicokinetic assessment.

    Observation:

    • A 37-year-old female presented with acetaminophen and ethanol ingestion and abdominal trauma.
    • She developed an ileus post-abdominal surgery, leading to delayed gastrointestinal absorption of acetaminophen.
    • Initial acetaminophen levels were high, with delayed clearance and a secondary peak after ileus resolution.

    Findings:

    • Acetaminophen toxicokinetics were significantly altered by delayed gastrointestinal absorption.
    • The patient experienced a prolonged period of detectable acetaminophen levels due to ileus.
    • Delayed absorption necessitated extended monitoring and treatment considerations.

    Implications:

    • Gastrointestinal motility status is crucial in managing acetaminophen poisoning.
    • Trauma and surgery-induced ileus require careful consideration for APAP treatment protocols.
    • Extended monitoring of acetaminophen levels may be necessary in patients with compromised GI function.