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Two Cases of Translocation t(3;6)(p14;p22): A Non Random Chromosomal Abnormality?

M Lessard¹, G Flandrin¹, F Valensi¹

¹a Laboratoire Central d'Hématologie, Hopital Saint-Louis, Paris, France.

Leukemia & Lymphoma

|July 28, 2016

Summary

This study identifies a rare chromosomal translocation, t(3;6)(p14;p22), in two leukemia patients. This finding suggests the translocation is nonrandom and linked to environmental exposures and secondary aberrations.

Keywords:

CML acute megakaryoblastic leukemia non random chromosomal abnormality t(3;6)translocation

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Area of Science:

Cytogenetics
Oncology
Molecular Biology

Background:

The short arm of chromosome 6 is implicated in chromosomal rearrangements in myelodysplastic syndromes/acute myeloid leukemia (MDS/ANLL) post-treatment.
Previous studies suggest a link between chemotherapy/radiotherapy and secondary chromosomal abnormalities in leukemia.

Purpose of the Study:

To report and analyze two novel cases of the uncommon chromosomal translocation t(3;6)(p14;p22).
To compare these cases with existing literature to determine if t(3;6) is a nonrandom event associated with specific exposures or genetic alterations.

Main Methods:

Karyotyping and chromosomal analysis were performed on bone marrow samples from two leukemia patients.
Case details, including medical history, treatment, and cytogenetic findings, were collected and compared with published data.

Main Results:

Two patients presented with t(3;6)(p14;p22), one with acute megakaryoblastic leukemia and another with chronic myeloid leukemia.
Both patients had a history of occupational exposure or prior treatment (chemo/radiotherapy, Hydroxyurea).
The translocation was associated with other secondary aberrations, including del(5)(q14q31) and -7, and involved known oncogene (pim-1) and fragile sites (3p14).

Conclusions:

The uncommon translocation t(3;6)(p14;p22) appears to be nonrandom.
This translocation may be a marker for secondary leukemia, potentially linked to mutagenic exposures and specific genetic alterations.