Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Connective Tissues01:11

Introduction to Connective Tissues

19.8K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
19.8K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

4.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.4K
Loose Connective Tissue01:26

Loose Connective Tissue

11.1K
Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
11.1K
Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

3.0K
Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
3.0K
Extracellular Matrix01:26

Extracellular Matrix

6.4K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
6.4K
Functions of Connective Tissues01:17

Functions of Connective Tissues

21.6K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
21.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why physicians underuse patient-reported outcomes in atopic dermatitis and chronic urticaria - Insights from the UCARE/ADCARE PROMUSE study.

The World Allergy Organization journal·2026
Same author

Factors Associated with Symptomatic Dermographism: Findings from the UCARE PREVALENCE-D Study.

American journal of clinical dermatology·2026
Same author

Randomized dose-finding study of anti-KIT barzolvolimab in patients with chronic spontaneous urticaria.

The Journal of allergy and clinical immunology·2026
Same author

Family quality-of-life burden in chronic spontaneous urticaria: A multicentre study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Long-term safety and efficacy of secukinumab in paediatric severe plaque psoriasis: 236-week, Phase 3 trial results.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

The Prevalence of Symptomatic Dermographism: Results of the International UCARE PREVALENCE-D Study.

Allergy·2025

Related Experiment Video

Updated: Mar 17, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
06:50

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

3.3K

Adipokines in connective tissue diseases.

Karolina Sawicka1, Dorota Krasowska2

  • 1Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Poland. k.sawicka10@gmail.com.

Clinical and Experimental Rheumatology
|July 28, 2016
PubMed
Summary

Adipokines, signaling molecules from fat tissue, are linked to metabolic syndrome and inflammation. This review explores their role in connective tissue diseases, including potential links to cardiovascular and rheumatic conditions.

More Related Videos

Identification and Dissection of Diverse Mouse Adipose Depots
06:31

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

45.8K
An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

4.4K

Related Experiment Videos

Last Updated: Mar 17, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
06:50

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

3.3K
Identification and Dissection of Diverse Mouse Adipose Depots
06:31

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

45.8K
An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

4.4K

Area of Science:

  • Endocrinology and Immunology
  • Rheumatology
  • Metabolic Diseases

Background:

  • Adipokines are signaling molecules produced by white adipose tissue (WAT).
  • Their roles in metabolic syndrome, inflammation, and autoimmunity are established.
  • Evidence suggests a potential link between adipokines, cardiovascular diseases (CVDs), and rheumatic diseases.

Purpose of the Study:

  • To review the current literature on the role of adipokines in rheumatic diseases.
  • To highlight the involvement of specific adipokines like leptin, resistin, adiponectin, chemerin, and visfatin.
  • To explore novel adipokines and their potential impact on connective tissue diseases.

Main Methods:

  • Literature review of scientific articles.
  • Focus on studies investigating adipokines in the context of rheumatic and connective tissue diseases.
  • Analysis of the pathogenetic mechanisms linking adipokines to these conditions.

Main Results:

  • Adipokines play a significant role in the pathogenesis and consequences of metabolic syndrome.
  • They are implicated in regulating inflammatory processes relevant to connective tissue diseases.
  • Specific adipokines (leptin, resistin, adiponectin, chemerin, visfatin) show potential links to rheumatic conditions.

Conclusions:

  • Adipokines are crucial mediators in metabolic and inflammatory processes.
  • There is a plausible connection between adipokine dysregulation and the development or progression of rheumatic diseases.
  • Further research into novel adipokines may reveal new therapeutic targets for connective tissue diseases.