Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

3.8K
The pathophysiology of pneumonia involves the following steps:
3.8K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

1.0K
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1.0K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

1.6K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.6K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

17.9K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
17.9K
Inflammation01:38

Inflammation

63.8K
Overview
63.8K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of a structured case report on self-reported responses to simulated emergency scenarios: a randomized survey-based study.

Scientific reports·2026
Same author

Comparison of Blood Culture Contamination Rates Between Initial Central Venous Puncture and Catheter Hub Sampling.

Critical care medicine·2026
Same author

Development Process of a Clinical Decision Support System for Empiric Antibiotic Therapies in Patients With Sepsis: Case Study.

JMIR medical informatics·2026
Same author

Pharmacokinetics of Landiolol and Its Metabolite M1 During Renal Replacement Therapy in Septic Shock Patients: A Sub-Study of the Landi-SEP Trial.

European journal of drug metabolism and pharmacokinetics·2026
Same author

Impaired tissue perfusion in high-risk patients having major abdominal surgery: a multicenter observational study.

Critical care (London, England)·2026
Same author

Hydrocortisone versus dexamethasone in cerebral salt-wasting after aneurysmal subarachnoid hemorrhage.

Brain & spine·2026

Related Experiment Video

Updated: Mar 17, 2026

Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

56.5K

[Pathophysiology of sepsis].

Christian Ertmer, Sebastian Rehberg

    Deutsche Medizinische Wochenschrift (1946)
    |July 28, 2016
    PubMed
    Summary

    Sepsis triggers a widespread immune response, leading to organ failure through inflammation and immune suppression. Early intervention is crucial as organ dysfunction can be fatal.

    Area of Science:

    • Immunology
    • Pathophysiology
    • Critical Care Medicine

    Background:

    • Sepsis involves a complex immune response, not just initial inflammation but also delayed immune suppression.
    • Endothelial dysfunction and sepsis-induced coagulopathy are key contributors to sepsis progression.

    Purpose of the Study:

    • To elucidate the multifaceted pathomechanisms underlying sepsis-induced multiple organ failure.
    • To highlight the clinical manifestations and consequences of sepsis-related circulatory disorders.

    Main Methods:

    • Review of current evidence on immune response in sepsis.
    • Analysis of pathomechanisms including endothelial dysfunction and coagulopathy.
    • Description of clinical microcirculatory and macrocirculatory changes.

    More Related Videos

    A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
    05:56

    A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

    Published on: February 20, 2021

    2.5K
    A Data-Driven Approach to Quantifying Immune States in Sepsis
    07:42

    A Data-Driven Approach to Quantifying Immune States in Sepsis

    Published on: February 7, 2025

    571

    Related Experiment Videos

    Last Updated: Mar 17, 2026

    Cecal Ligation Puncture Procedure
    11:53

    Cecal Ligation Puncture Procedure

    Published on: May 7, 2011

    56.5K
    A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
    05:56

    A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

    Published on: February 20, 2021

    2.5K
    A Data-Driven Approach to Quantifying Immune States in Sepsis
    07:42

    A Data-Driven Approach to Quantifying Immune States in Sepsis

    Published on: February 7, 2025

    571

    Main Results:

    • Sepsis-induced multiple organ failure results from a dysregulated immune response.
    • Impaired oxygen transport and cytopathic hypoxia contribute to organ dysfunction.
    • Mortality can reach 70% in cases of multiple organ failure.

    Conclusions:

    • Understanding the intricate interactions of immune mediators is vital for sepsis management.
    • Clinical interventions must address both circulatory impairments and cellular hypoxia.
    • Prompt recognition and treatment of sepsis are critical to reduce high mortality rates.