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Updated: Mar 17, 2026
An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
Respiratory Syncytial Virus (RSV): Neutralizing Antibody, a Correlate of Immune Protection
Pedro A Piedra1,2,3, Anne M Hause4,5, Letisha Aideyan4
1Department of Molecular Virology and Microbiology, Baylor College of Medicine, BCM MS280, One Baylor Plaza, Houston, TX, 77030, USA. ppiedra@bcm.edu.
Abstract:
Assays that measure RSV-specific neutralizing antibody activity are very useful for evaluating vaccine candidates, performing seroprevalence studies, and detecting infection. Neutralizing antibody activity is normally measured by a plaque reduction neutralization assay or by a microneutralization assay with or without complement. These assays measure the functional capacity of serum (or other fluids) to neutralize virus infectivity in cells as compared to ELISA assays that only measure the binding capacity against an antigen. This chapter discusses important elements in standardization of the RSV-specific microneutralization assay for use in the laboratory.
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