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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Related Experiment Video

Updated: Mar 17, 2026

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
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[Kidney transplantation in old age].

C Kurschat1

  • 1Klinik II für Innere Medizin, Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland. christine.kurschat@uk-koeln.de.

Zeitschrift Fur Gerontologie Und Geriatrie
|July 29, 2016
PubMed
Summary

Kidney transplantation significantly improves life expectancy and quality of life for older adults compared to dialysis. Thorough evaluation and living donor transplants offer the best outcomes for elderly kidney patients.

Keywords:
AgingEurotransplant senior programRenal replacement therapySurvivalTransplant function

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Area of Science:

  • Nephrology
  • Geriatrics
  • Transplantation Medicine

Background:

  • Older patients face challenges with dialysis, including shorter life expectancy and reduced quality of life.
  • Kidney transplantation offers potential benefits for elderly individuals, but careful assessment is crucial.
  • The Eurotransplant Senior Program (ESP) was established to facilitate kidney transplantation for older recipients.

Purpose of the Study:

  • To evaluate the benefits of kidney transplantation in older patients.
  • To assess the effectiveness of the Eurotransplant Senior Program (ESP).
  • To compare living donor transplantation with deceased donor transplantation for elderly recipients.

Main Methods:

  • Review of outcomes for older patients undergoing kidney transplantation versus remaining on dialysis.
  • Analysis of results from the Eurotransplant Senior Program (ESP) involving donors and recipients aged 65 and older.
  • Comparison of living donor kidney transplantation with deceased donor kidney transplantation in elderly populations.

Main Results:

  • Older patients benefit significantly from kidney transplantation, experiencing increased life expectancy and improved quality of life compared to dialysis.
  • The ESP program successfully shortens waiting times and cold ischemia for older recipients.
  • Living donor kidney transplantation demonstrates superior long-term function and spontaneous rates compared to deceased donor transplantation for older recipients.

Conclusions:

  • Kidney transplantation is a beneficial treatment option for older patients, enhancing both survival and quality of life.
  • While the ESP program improves access to deceased donor kidneys for older adults, living donor transplantation remains the preferred option.
  • Individualized patient evaluation, including geriatric assessments, is essential to determine suitability for kidney transplantation.