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Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models
Vinothkumar Rajan1, Graham Dellaire2,3, Jason N Berman4,5,6
1Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada, B3H 4R2.
Methods in Molecular Biology (Clifton, N.J.)
|July 29, 2016
Abstract:
The zebrafish is a widely accepted model to study leukemia. The major advantage of studying leukemogenesis in zebrafish is attributed to its short life cycle and superior imaging capacity. This chapter highlights using transgenic- and xenograft-based models in zebrafish to study a specific leukemogenic mutation and analyze therapeutic responses in vivo.
