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Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on
Michele E Barbour1, Sarah E Maddocks2, Helena J Grady1,3
1Oral Nanoscience, School of Oral & Dental Sciences, University of Bristol, UK.
Aim:
In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials.
Materials & Methods:
CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure.
Results:
Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis.
Conclusion:
CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.
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