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T wave amplitude in lead aVR as a novel diagnostic marker for cardiac sarcoidosis

Yoshihiro Tanaka1, Tetsuo Konno2,3, Shohei Yoshida1

  • 1Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1, Takara-machi, Kanazawa, 920-8641, Japan.

Heart and Vessels
|July 29, 2016
PubMed

Insights

Identifying cardiac involvement in sarcoidosis is crucial. T wave amplitude in lead aVR (TWAaVR) shows promise, especially when combined with bundle branch block (BBB), for detecting cardiac issues in sarcoidosis patients.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Pulmonology

Background:

  • Sarcoidosis can lead to sudden cardiac death due to cardiac involvement (CI).
  • Early identification of CI in sarcoidosis is essential for patient management.
  • The diagnostic utility of lead aVR parameters, specifically T wave amplitude in lead aVR (TWAaVR), for CI in sarcoidosis remains under-investigated.

Purpose of the Study:

  • To evaluate the diagnostic value of TWAaVR in identifying cardiac involvement in sarcoidosis patients.
  • To compare the effectiveness of TWAaVR with conventional electrocardiography parameters like bundle branch block (BBB).
  • To assess the combined diagnostic performance of TWAaVR and BBB for CI in sarcoidosis.

Main Methods:

  • Retrospective analysis of 93 sarcoidosis patients (2006-2014).
  • Assessment of T wave amplitude in lead aVR (TWAaVR) and bundle branch block (BBB) for detecting cardiac involvement.
  • Comparison of diagnostic values using sensitivity, specificity, and area under the curve (AUC).

Main Results:

  • TWAaVR demonstrated high specificity (92%) and moderate sensitivity (39%) for CI at a cutoff of -0.08 mV.
  • Combining TWAaVR with BBB significantly improved diagnostic performance for CI (AUC: 0.79-0.92).
  • TWAaVR and BBB were identified as independent electrocardiography predictors of CI in sarcoidosis.

Conclusions:

  • Elevated TWAaVR is associated with cardiac involvement in sarcoidosis.
  • The combination of BBB and TWAaVR offers a valuable screening tool for cardiac involvement in sarcoidosis.
  • Further research into electrocardiography markers for CI in sarcoidosis is warranted.

Keywords:
Cardiac involvementElectrocardiogramLead aVRSarcoidosis

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