Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment

Rare side effects of nonsteroidal antiinflammatory drugs are recognized with increasing frequency. Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus. We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.