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Clinical Features and Peripheral Blood T Lymphocyte Subsets in Hand, Foot, and Mouth Disease According to Different

Jian-Fang Zhou1, Zhi-Yong Chen2, Shan-Ming Yang3

  • 1Department of Infectious Diseases, Fenghua People's Hospital, Fenghua, Zhejiang Province, 315500, China. jianfangzhoucn@126.com.

Indian Journal of Pediatrics
|July 29, 2016
PubMed

Insights

Enterovirus 71 (EV71) infection in children with hand, foot, and mouth disease is linked to lower CD4+ T-cell counts compared to Coxsackie A16. Fecal and throat swabs are more effective for enterovirus detection than serum.

Area of Science:

  • Pediatric Infectious Diseases
  • Immunology
  • Virology

Background:

  • Hand, foot, and mouth disease (HFMD) is a common viral illness in children.
  • Enterovirus (EV) infections, including EV71 and Coxsackie A16 (CoxA16), are primary causes of HFMD.
  • Understanding the immunological impact of different EV strains is crucial for prognosis.

Purpose of the Study:

  • To examine alterations in T lymphocyte subsets during HFMD caused by various enteroviruses in children.
  • To compare the diagnostic yield of different sample types for enterovirus detection.

Main Methods:

  • Peripheral blood was collected for T lymphocyte subset analysis.
  • Serum, throat swab, and fecal samples were tested for enterovirus using molecular methods.
  • Statistical analysis was performed to compare detection rates and lymphocyte subset counts between groups.

Main Results:

  • Fecal and throat swab samples showed significantly higher enterovirus detection rates than serum samples (P < 0.01).
  • Children infected with EV71 had significantly lower CD4+ T-lymphocyte counts compared to those infected with CoxA16 (P < 0.05).

Conclusions:

  • Throat swabs and fecal samples are superior to serum for diagnosing enterovirus infections in children with HFMD.
  • EV71 infection is associated with a more pronounced reduction in CD4+ T-cells, suggesting a potentially poorer clinical outcome compared to CoxA16 infection.
Abstract

Keywords:
Clinical featuresHand-foot-and-mouth diseaseT lymphocyte subsets in peripheral blood

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