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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
[To improve the accessibility of hepatitis B treatment]
1Department of Microbiology and Center of Infectious Diseases, Peking University Health Science Center, Beijing 100191, China.
Insights
Chronic hepatitis B affects 90 million in China, with millions needing urgent treatment. Improving access to antiviral drugs requires price reductions and expanded insurance coverage.
Area of Science:
- Hepatology
- Public Health
- Pharmacoeconomics
Background:
- Chronic hepatitis B represents a significant health burden in China, affecting an estimated 90 million individuals.
- Approximately 7.4 million people with chronic hepatitis B are at high risk of advanced liver disease and cancer, necessitating urgent treatment.
- Current antiviral treatment accessibility is low, with only 12.5% of patients receiving necessary medication.
Discussion:
- The low uptake of antiviral therapy highlights critical barriers to treatment access.
- Addressing the substantial burden of chronic hepatitis B requires multifaceted strategies to improve drug affordability and availability.
- Policy interventions are crucial to ensure timely and effective management of chronic hepatitis B.
Key Insights:
- A significant gap exists between the number of individuals requiring chronic hepatitis B treatment and those currently receiving it.
- Reducing the cost of antiviral medications is a primary factor in enhancing treatment accessibility.
- Integrating antiviral drugs into national essential drug lists and reimbursement schemes is vital.
Outlook:
- Implementing government-led price negotiations and reconsidering patent registrations for drugs posing public health risks can lower costs.
- Expanding insurance coverage for antiviral treatments in both inpatient and outpatient settings will improve patient access.
- Proactive policy measures are essential to mitigate the long-term health consequences of chronic hepatitis B in China.
Abstract:
The burden of chronic hepatitis B is substantial in China. An estimated 90 million people are living with chronic hepatitis B. About 7.4 million people are at high risk of advance stage liver disease and cancer due to chronic hepatitis B and who urgently require treatment. However, only 12.5% of chronic hepatitis B patients are receiving antiviral treatment at present. In order to improve the accessibility of antiviral treatment for chronic hepatitis B we should decrease the price of antiviral drugs; to bring antiviral drugs into the national essential drugs list; to include antiviral drugs in both inpatient and outpatient reimbursement category; to apply the mechanisms for drug price reduction such as rejecting the patent registration for drugs with public health risk and harm to welfare policy; initiating government unified price negotiations with drug companies.
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