Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Descriptive analysis of recovery-related outcomes following cognitive behavioural therapy in a Japanese clinical sample using definitions from the Talking Therapies for Anxiety and Depression programme.

Behavioural and cognitive psychotherapy·2026
Same author

Feasibility of Videoconference-Based Cognitive Behavioral Therapy for Somatic Symptom Disorder: Single-Arm Pilot Trial.

JMIR formative research·2026
Same author

Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium.

medRxiv : the preprint server for health sciences·2026
Same author

Relationships among highly sensitive personality (HSP), neuroticism, mental health, neurodevelopmental traits, and adverse childhood experiences (ACEs).

PCN reports : psychiatry and clinical neurosciences·2026
Same author

Bayesian randomised controlled trial of guided parent-delivered cognitive behavioural therapy for children with anxiety disorders via remote sessions in Japan: a study protocol.

BMJ open·2026
Same author

Disrupted Salience Network and Its Deteriorated Interaction With the Central Executive Network in Anorexia Nervosa: A Multicenter Study.

Biological psychiatry global open science·2026

Related Experiment Video

Updated: Mar 17, 2026

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex
10:45

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex

Published on: December 19, 2012

20.9K

Normal lactate concentration range in the neonatal brain.

Moyoko Tomiyasu1, Noriko Aida2, Jun Shibasaki3

  • 1Department of Molecular Imaging & Theranostics, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan; Department of Radiology, Kanagawa Children's Medical Center, 2-138-4 Mutsukawa, Minami-ku, Yokohama 232-8555, Japan; Research Center for Child Mental Development, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

Magnetic Resonance Imaging
|July 29, 2016
PubMed
Summary

Neonatal brain lactate levels are higher than in older children, but show no correlation with postconceptional age. Establishing normal lactate ranges aids in diagnosing brain conditions in infants.

Keywords:
Brain lactate concentrationDiagnostic indexMR spectroscopyNeonates

More Related Videos

Spinal Cord Electrophysiology
04:59

Spinal Cord Electrophysiology

Published on: January 18, 2010

22.3K
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

1.1K

Related Experiment Videos

Last Updated: Mar 17, 2026

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex
10:45

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex

Published on: December 19, 2012

20.9K
Spinal Cord Electrophysiology
04:59

Spinal Cord Electrophysiology

Published on: January 18, 2010

22.3K
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

1.1K

Area of Science:

  • Neuroscience
  • Biochemistry
  • Medical Imaging

Background:

  • Lactate peaks in neonatal brain magnetic resonance spectroscopy (MRS) scans can occur even in healthy infants.
  • Establishing a definitive normal range for neonatal brain lactate concentration is clinically valuable for accurate diagnosis.

Purpose of the Study:

  • To investigate and determine the normal range of lactate concentration in the neonatal brain.
  • To assess the relationship between brain lactate levels and postconceptional age in neonates and overall age in infants and children.

Main Methods:

  • Single-voxel MRS data were acquired from the basal ganglia (BG) and centrum semiovale (CS) of 48 healthy neonates, 9 infants, and 20 children using a 3T scanner.
  • Lactate concentrations were quantified using the LCModel program.
  • Correlations between regional lactate concentration and postconceptional age (PCA) or age were analyzed.

Main Results:

  • Median lactate concentrations in neonates were 0.77mM in BG and 0.77mM in CS.
  • Lactate concentrations significantly decreased with age across all subjects (Spearman: BG, ρ=-0.38, p=0.003; CS, ρ=-0.57, p<0.001).
  • No significant correlation was found between neonatal lactate concentration and PCA in either region.

Conclusions:

  • Normal ranges for neonatal brain lactate concentration were established, aiding diagnostic capabilities.
  • Further research into developmental changes in brain lactate is needed to understand higher neonatal concentrations and improve diagnostic accuracy.