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Updated: Mar 17, 2026
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
Risk Factors of Lymph Nodes Metastases by Endometrial Cancer: A Retrospective One-center Study
Mustafa Zelal Muallem1, Jalid Sehouli2, Jumana Almuheimid2
1Department of Gynecology, Campus Virchow-Klinikum, Charité Medical University, Berlin, Germany Mustafa-Zelal.Muallem@charite.de.
Background/Aim:
We aimed to identify the surgical-pathological risk factors separately for pelvic and para-aortic lymph nodes (LN) metastases in endometrial cancer (EC).
Patients And Methods:
The study cohort consisted of 179 patients with first diagnosis of EC, who were operated in our Institution between 2007 and 2014.
Results:
Pelvic and para-aortic LN dissection was performed in 115 patients (64.2%). The positive pelvic and para-aortic LN were diagnosed in 11.3% and 16.1% of cases, respectively. Patients with bad differentiated tumors (G3) showed about 5-times more risk to have affected LN. Deep infiltration of myometrium elevated the risk of pelvic LN infiltration 5 times and of para-aortic LN infiltration 14 times. G3, myometrial infiltration >50% and type II endometrial cancer correlated with a worse progression free survival (PFS) and overall survival (OS).
Conclusion:
Tumor grade and deep myometrial invasion were the only significant predictors of pelvic and para-aortic lymph node metastases.
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