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2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia
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Complete, bilateral hippocampal ischemia: a case series.

Juan E Small1, P Monroe Butler2,3, Yuval Zabar3

  • 1a Department of Radiology , Lahey Hospital and Medical Center , Burlington , MA , USA.

Neurocase
|July 29, 2016
PubMed
Summary

Acute hippocampal ischemia, a rare cause of amnesia, was observed in four patients. Opioid exposure was identified in three cases, suggesting a link between opioid toxicity and this condition.

Keywords:
Hippocampusamnesiaheroinmemoryopioids

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Area of Science:

  • Neurology
  • Toxicology
  • Radiology

Background:

  • Acute and complete ischemia of the hippocampi is a rare cause of amnesia.
  • Hippocampal damage can lead to significant memory impairment.

Purpose of the Study:

  • To describe the clinical and radiological features of patients with acute hippocampal ischemia.
  • To investigate potential etiologies, particularly toxic exposures, associated with this condition.

Main Methods:

  • Retrospective case series of four patients presenting with acute hippocampal ischemia.
  • Review of clinical presentations, imaging findings, and toxicology results.
  • Literature review on complete hippocampal ischemia and its causes.

Main Results:

  • Four cases of acute and complete hippocampal ischemia were identified over a 3-year period.
  • Toxicology screening was positive for opioids in three patients.
  • The fourth patient had a history of heroin use, suggesting a possible toxic exposure link.

Conclusions:

  • Complete hippocampal ischemia may be strongly associated with toxic exposure, particularly opioids.
  • Further research is needed to establish the etiology, nature, and prevalence of this clinico-radiologic entity.