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Related Experiment Videos

Complement-mediated hemodynamic depression in the early postburn period.

W J Schirmer1, J M Schirmer, G B Naff

  • 1Department of Surgery, Veterans Administration Medical Center, Cleveland, OH 44106.

The Journal of Trauma
|July 1, 1989
PubMed
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Complement activation significantly impacts early cardiac output after severe burns. Depleting complement improves hemodynamics and cardiac function in post-burn injury models.

Area of Science:

  • Physiology
  • Immunology
  • Trauma Research

Background:

  • Severe thermal injury triggers complex systemic responses.
  • The role of the complement system in post-burn hemodynamics is not fully understood.

Purpose of the Study:

  • To investigate the influence of complement activation on systemic hemodynamics after severe thermal injury.
  • To determine the effects of complement depletion on cardiac output, mean arterial pressure, and systemic vascular resistance post-burn.

Main Methods:

  • Rats were treated with cobra venom factor to deplete complement or saline.
  • Animals underwent a 50% TBSA full-thickness scald burn or sham procedure.
  • Hemodynamic parameters (CO, MAP, SVR, heart rate, stroke volume) were measured at various time points post-burn.

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Main Results:

  • Burn injury in normocomplementemic rats caused early depression in cardiac output and mean arterial pressure, with increased systemic vascular resistance.
  • Complement depletion attenuated the early hemodynamic decline and reduced the rise in systemic vascular resistance.
  • Complement depletion improved heart rate, stroke volume, and preserved/enhanced late cardiac function.

Conclusions:

  • Complement activation contributes significantly to the early depression of cardiac output following severe thermal injury.
  • Modulating complement activity may represent a therapeutic strategy to improve outcomes after burn injuries.