Search research articles

Search research articles

Related Experiment Videos

Vesicoureteral reflux and voiding dysfunction: a prospective study.

¹Department of Pediatrics, Hospital de Santa Maria, Universidade Classica de Lisboa, Lisbon, Portugal.

The Journal of Urology

|August 1, 1989

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Renal trauma in children.

Canadian journal of surgery. Journal canadien de chirurgie·1979

Same journal

Editorial Comment.

The Journal of urology·2026

Same journal

Editorial Comment.

The Journal of urology·2026

Same journal

Editorial Comment.

The Journal of urology·2026

Same journal

Uro-Science.

The Journal of urology·2026

Same journal

Editorial Comment.

The Journal of urology·2026

Same journal

Editorial Comment.

The Journal of urology·2026

See all related articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Medical treatment targeting bladder instability and vesicoperineal incoordination effectively resolved primary vesicoureteral reflux in children. This approach showed significantly higher success rates compared to antibiotic prophylaxis alone.

Area of Science:

Pediatric Urology
Urodynamics
Pharmacological Interventions

Background:

Primary vesicoureteral reflux (VUR) in children can be associated with elevated bladder pressures and abnormal perineal muscle activity.
Previous treatment of VUR primarily involved prophylactic antibiotics, with variable success rates.
The role of bladder dysfunction and vesicoperineal incoordination in VUR pathogenesis requires further investigation.

Purpose of the Study:

To evaluate the efficacy of medical management targeting urodynamic abnormalities in children with primary vesicoureteral reflux.
To compare the outcomes of this targeted medical treatment with those of traditional antibiotic prophylaxis.

Main Methods:

Prospective study of 53 children with primary VUR treated with medications (baclofen, flavoxate, dicyclomine, diazepam) for urodynamic dysfunctions.

Related Experiment Videos

Retrospective review of 48 children with primary VUR treated with prophylactic antibiotics only.

Urodynamic evaluations were performed before and after treatment to assess bladder pressures and perineal muscle activity.

Main Results:

In the prospective group, 91.8% of ureters showed complete resolution of reflux, and 8.2% were downgraded after medical treatment.
Post-treatment urodynamics revealed normalized bladder pressures in 83.7% of children whose reflux resolved.
The antibiotic-only group had significantly lower resolution rates (53.7%) and higher rates of unchanged or upgraded reflux.

Conclusions:

Vesicoperineal incoordination and bladder instability are significant factors in the development and persistence of primary VUR.
Targeted medical treatment addressing these urodynamic factors offers a highly effective therapeutic strategy for pediatric VUR.
This approach demonstrates superior outcomes compared to prophylactic antibiotic therapy alone.