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Updated: Mar 17, 2026
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
Published on: June 13, 2019
Interdigitating Reticulum Cell Sarcoma Positive immunohistochemistry for HLA-DR and two other activation antigens,
C S Papadimitriou1, M C Bai1, D G Stephanou1
1a Departments of Pathology, School of Medicine, University of Ioannina, Ioannina, Greece.
Abstract:
This communication reports a case of the rare interdigitating reticulum cell (IDRC) sarcoma of lymph nodes in a 46-year-old man. Extensive immunophenotypic analysis on paraffin and frozen sections revealed positivity on the neoplastic cells for protein S-100 as well as for antigens CD1, HLA-DR, CD4, CD25 (IL2R) and CD30 (Ki-1). The simultaneous positivity for the three activation antigens CD30, HLA-DR, and IL2R, a phenomenon mostly described in H and S-R cells of Hodgkin's disease, is discussed in particular.
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