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Related Experiment Video

Updated: Mar 17, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Fabiano Barbiero¹, Manuela Giangreco, Federica Edith Pisa

¹Dipartimento di Scienze Mediche e Biologiche, Università di Udine, Udine, Italia Dipartimento di Medicina Clinica e Sperimentale, Università di Parma, Parma, Italia Servizio Prevenzione Igiene e Sicurezza negli Ambienti di Lavoro (SPISAL), ULSS n. 12, Mestre, Italia. fabiano.barbiero@uniud.it.

La Medicina Del Lavoro

|July 29, 2016

Summary

This summary is machine-generated.

Estimating mesothelioma incidence in Italian workers is challenging due to unavailable national rates. Using weighted mean incidence rates offers a valid alternative for Standardized Incidence Rate Ratio (SIR) calculations.

Keywords:

Analisi di Sensibilità, Sir, Mesotelioma, Amianto/Sensitivity Analysis, Sir, Mesothelioma, Asbestos

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Area of Science:

Epidemiology
Occupational Health
Cancer Research

Background:

Mesothelioma incidence in Italy varies geographically, with high rates in Genoa and Friuli Venezia Giulia (FVG).
National standard incidence rates for mesothelioma are unavailable before 2006.
Accurate estimation of mesothelioma risk in asbestos-exposed workers is crucial for health surveillance.

Purpose of the Study:

To estimate the Standardized Incidence Rate Ratio (SIR) for mesothelioma in a cohort of former asbestos-exposed workers.
To address challenges in SIR calculation when national rates are unavailable and regional rates are biased by cohort size.

Main Methods:

A sensitivity analysis was conducted on a cohort of 2,488 men.
Utilized 14 Italian cancer registries with complete data from 1995-2007.
Calculated weighted mean rates from North-Italian registries (Mean W10) and all 14 registries (Mean W14), and used FVG standard rates for comparison.

Main Results:

Observed 25 incident mesothelioma cases between 1995-2007.
Expected cases ranged from 2.00 (Mean W14) to 2.56 (FVG standard rate).
Resulting SIRs were 12.49 (Mean W14) and 9.76 (FVG standard rate), indicating significant estimation distortions with FVG rates.

Conclusions:

Using Friuli Venezia Giulia (FVG) rates as a standard did not significantly distort expected mesothelioma case calculations.
However, using FVG rates led to remarkable distortions in Standardized Incidence Rate Ratio (SIR) estimations.
Weighted mean standard incidence rates present a viable alternative for SIR estimation when national rates are absent.