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Cancerome: A hidden informative subnetwork of the diseasome
Mahdi Jalili1, Ali Salehzadeh-Yazdi2, Marjan Yaghmaie1
1Hematology, Oncology and SCT Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:
Neoplastic disorders are a leading cause of mortality and morbidity worldwide. Studying the relationships between different cancers using high throughput-generated data may elucidate undisclosed aspects of cancer etiology, diagnosis, and treatment. Several studies have described relationships between different diseases based on genes, proteins, pathways, gene ontology, comorbidity, symptoms, and other features. In this study, we first constructed an integrated human disease network based on nine different biological aspects, including molecular, functional, and clinical features. Next, we extracted the cancerome as a cancer-related subnetwork. Further investigation of cancerome could reveal hidden mechanisms of cancer and could be useful in developing new diagnostic tests and effective new drugs.
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