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Updated: Mar 17, 2026
Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5
Naoko Iwasaki1, Masashi Tsurumi2, Kuniya Asai2
1Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan; Tokyo Women's Medical University Institute of Medical Genetics, Tokyo, Japan; Tokyo Women's Medical University Institute of Integrated Medical Science, Tokyo, Japan.
Abstract:
The hepatocyte nuclear factor 1β gene (HNF1B) is responsible for maturity-onset diabetes of the young type 5 (MODY5), which is characterized by early-onset diabetes mellitus and urogenital malformations. HNF1B is expressed during visceral endoderm formation. We identified a disruption of the great pancreatic artery in a patient with MODY5 with no pancreatic body or tail. Our finding supports the significance of HNF1B in the development of the pancreas.
