Related Experiment Videos
[Clinical study on sulbactam/ampicillin in the pediatric field]
E Takeda1, T Hosoda, T Ichioka
1Department of Pediatrics, School of Medicine, University of Tokushima.
Insights
Sulbactam/ampicillin (SBT/ABPC) showed excellent clinical efficacy in treating pediatric bacterial infections, with no severe side effects observed. This antibiotic combination is a promising option for various acute infections in children.
Area of Science:
- Infectious Diseases
- Pediatric Medicine
- Pharmacology
Context:
- Acute bacterial infections pose significant health challenges in pediatric populations.
- Intravenous administration of antibiotics is crucial for severe infections.
- Evaluating novel antibiotic combinations is essential for effective treatment strategies.
Purpose:
- To assess the clinical and bacteriological efficacy of sulbactam/ampicillin (SBT/ABPC) in pediatric patients.
- To determine the safety profile of SBT/ABPC in children with acute infections.
Summary:
- A total of 18 pediatric patients (3 months to 10 years 10 months) with acute infections received intravenous SBT/ABPC.
- Clinical responses were excellent in 14 patients and good in 4.
- Bacteriological eradication was achieved in 7 of 8 isolated strains. Minor side effects like eosinophilia and thrombocytosis were noted in a few cases.
Impact:
- SBT/ABPC demonstrated significant effectiveness and a favorable safety profile for treating bacterial infections in children.
- The findings support the use of SBT/ABPC as a valuable therapeutic agent in pediatric infectious disease management.
- Further research could explore broader applications and optimal dosing in diverse pediatric infections.
Abstract:
A combination drug of sulbactam/ampicillin (SBT/ABPC) was intravenously administrated to 18 patients with ages 3 months to 10 years 10 months with various acute infections including 14 cases of pneumonia, 1 case each of tonsillitis, subacute bacterial endocarditis, empyema and suspected sepsis. Clinical responses were excellent in 14 cases and good in 4 cases. Bacteriological responses of 8 isolated strains were: 7 strains were eradicated and 1 strain was decreased. No side effect was observed in any case. Eosinophilia was observed in 2 cases, thrombocytosis in 2 cases, elevation of GOT in 1 case and elevations of GOT and GPT in 1 case. From the above results, it seemed that SBT/ABPC was a useful drug for the treatment of bacterial infections in the pediatric field.