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[Sepsis in patients with hematological diseases]
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|February 1, 1989
Summary
Sepsis is a serious complication in hematological disease patients. Gram-negative bacteria, particularly Pseudomonas aeruginosa, were common causes, with neutropenia and shock significantly impacting survival rates.
Area of Science:
- Hematology
- Infectious Diseases
- Critical Care Medicine
Context:
- Sepsis frequently complicates the treatment of severe hematological diseases.
- This study retrospectively analyzed sepsis cases in patients with hematological conditions at Yokohama City University Hospital between 1979 and 1986.
- A total of 309 patients with hematological diseases were included in the analysis.
Purpose:
- To analyze the incidence, causative organisms, and mortality rates of sepsis in patients with hematological diseases.
- To identify significant prognostic factors influencing patient outcomes in sepsis associated with hematological conditions.
Summary:
- Out of 309 patients, 73 (23.6%) developed sepsis, with a positive blood culture rate of 17.8%.
- Gram-negative bacilli (56.4%), notably Pseudomonas aeruginosa (19.2%), were the predominant pathogens. Fungal and anaerobic infections were less common.
- The overall mortality rate for sepsis in this cohort was 34.2%. Key prognostic factors included the degree and duration of neutropenia, the specific organism, concurrent shock, and the location of other infections.
Impact:
- This research highlights the significant burden of sepsis in hematological disease patients and identifies critical factors for risk stratification and management.
- Understanding these prognostic factors can aid clinicians in optimizing treatment strategies and improving patient outcomes in this vulnerable population.