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Related Concept Videos

The Respiratory System01:16

The Respiratory System

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The respiratory system is comprised of the organs that enable breathing. Air enters the nostrils and mouth, followed by the pharynx (throat) and larynx (voice box), which lead to the trachea (windpipe). In the thoracic cavity, the trachea splits into two bronchi that allow air to enter the lungs. The bronchi split into progressively smaller bronchioles and terminate in small groups of tiny sacs in the lungs called alveoli, where gas exchange occurs.
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Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

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Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
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Other Pulmonary Disorders01:17

Other Pulmonary Disorders

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Common Respiratory Disorders01:31

Common Respiratory Disorders

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Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
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Breathing01:05

Breathing

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The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
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Overview of Respiratory System01:23

Overview of Respiratory System

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The respiratory system is a complex biological apparatus that facilitates the exchange of gases, specifically oxygen and carbon dioxide, between our bodies and the environment. This system plays a vital role in the physiological process of respiration, an essential function for sustaining life.
What is the Respiratory System?
The respiratory system consists of a series of organs responsible for taking in oxygen and expelling carbon dioxide. The primary function of the respiratory system is to...
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Related Experiment Video

Updated: Mar 17, 2026

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
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Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

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Respiratory System Disease.

Danielle M Goetz1, Shipra Singh1

  • 1Pediatric Pulmonology, Jacobs School of Medicine, Women & Children's Hospital of Buffalo, State University of New York, 219 Bryant Street, Buffalo, NY 14222, USA.

Pediatric Clinics of North America
|July 30, 2016
PubMed
Summary

Cystic fibrosis (CF) primarily affects the respiratory system, leading to infections and lung disease. Emerging CFTR-targeted therapies offer new hope for managing this complex genetic disorder.

Keywords:
BronchiectasisCFTRCystic fibrosisLung diseaseLung functionPulmonary exacerbation

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Remote Laboratory Management: Respiratory Virus Diagnostics
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Area of Science:

  • Pulmonology
  • Genetics
  • Infectious Diseases

Background:

  • Cystic fibrosis (CF) is a genetic disorder primarily impacting the respiratory system, causing significant morbidity and mortality.
  • Defects in the cystic fibrosis transmembrane regulator (CFTR) gene lead to sinopulmonary infections by various pathogens, including Pseudomonas aeruginosa.
  • Early-onset lung disease in CF necessitates effective monitoring and treatment strategies.

Purpose of the Study:

  • To review the current understanding of sinopulmonary disease in cystic fibrosis.
  • To discuss current and emerging treatment modalities for CF-related lung disease.
  • To highlight the potential of personalized medicine, specifically CFTR modulators, in altering disease trajectory.

Main Methods:

  • Literature review of sinopulmonary involvement in cystic fibrosis.
  • Analysis of current therapeutic approaches including physiotherapy, medications, and surgery.
  • Examination of the role of novel CFTR correctors and potentiators.

Main Results:

  • Respiratory system involvement is the primary driver of morbidity and mortality in CF.
  • Recurrent sinopulmonary infections are a hallmark of the disease, caused by pathogens like P. aeruginosa.
  • Debate exists regarding optimal methods for monitoring lung function decline or improvement.

Conclusions:

  • Effective management of CF sinopulmonary disease requires a multi-faceted approach.
  • Personalized medicine, particularly CFTR modulators, represents a significant advancement in CF treatment.
  • These novel therapies hold the potential to fundamentally change the course of cystic fibrosis lung disease.