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Transplantation

Albert Faro1, Alexander Weymann1

  • 1Department of Pediatrics, Washington University in St. Louis, Campus Box 8116, 660 South Euclid Avenue, St Louis, MO 63110, USA.

Pediatric Clinics of North America
|July 30, 2016
PubMed

Insights

Lung and liver transplants offer hope for children with cystic fibrosis (CF) facing end-stage disease. However, successful outcomes require overcoming challenges like organ shortages and lifelong medical adherence.

Area of Science:

  • Pediatric medicine
  • Transplantation surgery
  • Genetics and rare diseases

Background:

  • Cystic Fibrosis (CF) significantly impacts children's health, often leading to end-stage lung or liver disease.
  • Despite medical advancements, a subset of CF patients requires organ transplantation for survival.

Purpose of the Study:

  • To review the indications for lung and liver transplantation in pediatric patients with Cystic Fibrosis.
  • To discuss the potential complications associated with these life-saving procedures.

Main Methods:

  • Literature review of pediatric Cystic Fibrosis transplantation cases.
  • Analysis of outcomes, complications, and management strategies.

Main Results:

  • Transplantation can extend life and improve quality of life for children with CF.
  • Significant barriers include donor organ scarcity, surgical risks, immunosuppression side effects, rejection, and adherence challenges.

Conclusions:

  • Lung and liver transplantation are viable options for select pediatric CF patients.
  • Multidisciplinary management is crucial to mitigate risks and optimize long-term results.

Keywords:
AllograftCystic fibrosisLiver transplantationLung transplantationRejection

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