Flow and pressure measurements in aneurysms and arteriovenous malformations with phase contrast MR imaging
M Ethan MacDonald1, Parviz Dolati2, Alim P Mitha2
1Biomedical Engineering, University of Calgary, Calgary, AB, Canada; Radiology, University of Calgary, Calgary, AB, Canada; Clinical Neuroscience, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Seaman Family Magnetic Resonance Research Centre, Foothills Medical Centre, Calgary, AB, Canada.
Purpose:
To explore phase contrast (PC) magnetic resonance imaging of aneurysms and arteriovenous malformations (AVM). PC imaging obtains a vector field of the velocity and can yield additional hemodynamic information, including: volume flow rate (VFR) and intravascular pressure. We expect to find lower VFR distal to aneurysms and higher VFR in vessels of the AVM.
Materials And Methods:
Five cerebral aneurysm and three AVM patients were imaged with PC techniques and compared to VFR of a healthy cohort. VFR was calculated in vessel segments in each patient and compared statistically to the healthy cohort by computing the z-score. Intravascular pressure was calculated in the aneurysms and in the nidus of each AVM.
Results:
We found that patients with aneurysm had z<-0.48 in vessels distal to the aneurysm (reduced flow), while AVM patients had z>6 in some vessels supplying and draining the nidus (increased flow). Pressures in aneurysms were highly variable between subjects and location, while in the nidus of the AVM patients; pressure trended higher in larger AVMs.
Conclusion:
The study findings confirm the expectation of lower distal flow in aneurysm and higher arterial and venous flow in AVM patients.
