Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cytoskeletal Linker Proteins - Plakins

Cytoskeletal Linker Proteins - Plakins

Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Value of cognitive fusion targeted and standard systematic transrectal prostate biopsy for prostate cancer diagnosis.

Asian journal of andrology·2024

Same author

Siglec-15 promotes progression of clear renal cell carcinoma.

Chinese medical journal·2021

Same author

[Advances in Pelvic Lymph Node Dissection for Bladder Cancer].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2020

Same author

Development and Initial Validation of the Novel Scale for Assessing Quality of Life of Prostate Cancer Patients Receiving Androgen Deprivation Therapy.

Chinese medical journal·2017

Same author

Establishment and Evaluation of Patient-Specific Virtual Ureteroscopy in Assisting Flexible Ureteroscopy for Urolithiasis.

Surgical innovation·2017

Same author

Knocking down glycoprotein nonmetastatic melanoma protein B suppresses the proliferation, migration, and invasion in bladder cancer cells.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine·2017

Search research articles

Related Experiment Video

Updated: Mar 17, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

Research Advances in CKLFSF-like MARVEL Transmembrane Domain Containing Member 3.

Feng-zhan Hu¹, Zheng-zuo Sheng¹, Cai-peng Qin¹

¹Department of Urology,Peking University People’s Hospital,Beijing 100044,China

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae

|July 30, 2016

Summary

Chemokine-like factor superfamily member 3 (CMTM3) acts as a tumor suppressor. Its restoration may inhibit cancer cell growth and invasion, suggesting CMTM3 as a potential target for cancer gene therapy.

More Related Videos

Efficient Production and Purification of Recombinant Murine Kindlin-3 from Insect Cells for Biophysical Studies

Efficient Production and Purification of Recombinant Murine Kindlin-3 from Insect Cells for Biophysical Studies

Published on: March 19, 2014

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

Published on: August 13, 2012

Related Experiment Videos

Last Updated: Mar 17, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

Efficient Production and Purification of Recombinant Murine Kindlin-3 from Insect Cells for Biophysical Studies

Efficient Production and Purification of Recombinant Murine Kindlin-3 from Insect Cells for Biophysical Studies

Published on: March 19, 2014

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

Published on: August 13, 2012

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Chemokine-like factor superfamily member (CKLFSF/CMTM) represents a novel class of tumor suppressor genes.
CMTM3 exhibits broad expression in normal human tissues, with notable presence in the testis, spleen, and peripheral blood mononuclear cells.
Conversely, CMTM3 expression is significantly down-regulated or undetectable in numerous carcinoma cell lines and tissues.

Purpose of the Study:

To review the advancements and potential therapeutic applications of CKLFSF3/CMTM3 in cancer.
To explore the role of CMTM3 in tumorigenesis, particularly its connection to the immune system and sex-related factors.
To identify CMTM3 as a potential novel target for gene therapies, especially for genitourinary tumors.

Main Methods:

Review of existing literature on CKLFSF3/CMTM3.
Analysis of gene expression patterns in normal versus cancerous tissues.
Investigation of the functional impact of CMTM3 restoration on carcinoma cell behavior.

Main Results:

CMTM3 expression is inversely correlated with cancer progression.
Restoration of CMTM3 can inhibit proliferation, migration, and invasion of carcinoma cells.
CMTM3 is implicated in immune system interactions and sex-associated aspects of tumorigenesis.

Conclusions:

CMTM3 demonstrates significant anti-tumor activity, positioning it as a promising candidate for cancer gene therapy.
Further research into the precise anti-tumor mechanisms of CMTM3 is warranted.
CMTM3 holds particular promise as a therapeutic target for genitourinary tumors.