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Related Experiment Video

Updated: Mar 17, 2026

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Indeterminate CT pulmonary angiogram: Why and does it matter?

Ju Hee Yeo1, Lifeng Zhou2, Remy Lim1

  • 1Department of Radiology, North Shore Hospital, Waitemata DHB, Auckland, New Zealand.

Journal of Medical Imaging and Radiation Oncology
|July 30, 2016
PubMed
Summary
This summary is machine-generated.

Six percent of CT pulmonary angiograms (CTPA) were indeterminate. The average Hounsfield unit of the pulmonary trunk was a key predictor of indeterminate CTPA, impacting diagnostic accuracy.

Keywords:
CTPAcontrastindeterminatepulmonary embolismsuboptimal

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Area of Science:

  • Radiology
  • Medical Imaging

Background:

  • Indeterminate CT pulmonary angiograms (CTPA) can lead to diagnostic uncertainty.
  • Assessing the rate and causes of indeterminate CTPA is crucial for improving diagnostic yield.

Purpose of the Study:

  • To determine the rate of indeterminate CTPA in a general hospital setting.
  • To identify factors contributing to indeterminate CTPA and their impact on patient outcomes.

Main Methods:

  • Retrospective review of 403 CTPA studies and reports.
  • Data collected included patient demographics, scan parameters, and average Hounsfield Unit (HU) of the pulmonary trunk.
  • Statistical analyses included univariate and multivariate regression.

Main Results:

  • 6% of CTPA studies were indeterminate (suboptimal or non-diagnostic).
  • Factors associated with indeterminate studies included patient weight, average pulmonary trunk HU, and effective dose.
  • In multivariate analysis, only average pulmonary trunk HU (OR=0.99) predicted indeterminate studies.
  • Common causes for indeterminate studies included suboptimal contrast enhancement, motion artifacts, and body habitus.

Conclusions:

  • Average Hounsfield Unit of the pulmonary trunk is a significant predictor of indeterminate CTPA.
  • Improving contrast enhancement and reducing motion artifacts can decrease indeterminate CTPA rates.