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In vitro toxicity testing of cigarette smoke based on the air-liquid interface exposure: A review

Xiang Li1

  • 1Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, No. 2 Fengyang Street, Zhengzhou 450001, China.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
|July 30, 2016
PubMed

Keywords:
Air-liquid interfaceCigarette smokeWhole smokein vitro toxicity

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...