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Precipitous Dehydroepiandrosterone Declines Reflect Decreased Physical Vitality and Function
Danielle N Rendina1, Carol D Ryff2, Christopher L Coe1
1Harlow Center for Biological Psychology and.
Summary
Lower levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) correlate with reduced physical vitality and increased chronic illness. Sustained hormone levels in older adults indicate a lower risk of frailty.
Area of Science:
- Endocrinology
- Gerontology
- Health Sciences
Background:
- Dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S) levels naturally decline with age.
- Significant individual variation exists in this decline, potentially indicating health status.
Purpose of the Study:
- To investigate the correlation between DHEA and DHEA-S levels and physical vitality indicators.
- To assess the association of hormone levels with chronic illness and pain.
Main Methods:
- Analysis of DHEA and DHEA-S levels in 1,214 participants aged 35-86 from the Midlife Development in the United States survey.
- Correlation of hormone levels with clinical health histories, physical functioning tests (grip strength, gait speed), and self-reported pain.
Main Results:
- Lower-than-expected DHEA and DHEA-S levels were linked to increased chronic illness and persistent pain.
- Reduced hormone levels correlated with poorer physical functioning, including grip strength and gait speed.
- Significant decrements in DHEA/DHEA-S were associated with diminished vigor and physical strength.
Conclusions:
- Age-related declines in DHEA and DHEA-S may be causally linked to reduced physical vitality.
- Sustained DHEA/DHEA-S secretion in older adults is associated with a reduced risk of frailty and associated ailments.
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