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Related Experiment Video

Updated: Mar 17, 2026

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HP1BP3 expression determines maternal behavior and offspring survival.

B P Garfinkel1,2, S Arad3,4, S M Neuner5

  • 1The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel. benny.garfinkel@mail.huji.ac.il.

Genes, Brain, and Behavior
|July 30, 2016
PubMed
Summary

Mice lacking heterochromatin protein 1 binding protein 3 (HP1BP3) showed reduced pup survival and impaired maternal behaviors, indicating HP1BP3

Keywords:
AnxietyHP1BP3chromatinepigeneticshistoneknockout mousematernal behaviormicroRNAsocialsurvival

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Area of Science:

  • Neuroscience
  • Epigenetics
  • Behavioral Biology

Background:

  • Postpartum maternal behavior is crucial for mammalian survival and reproduction.
  • Epigenetic regulation plays a complex role in mediating maternal behaviors.
  • Heterochromatin protein 1 binding protein 3 (HP1BP3) is a novel epigenetic repressor involved in postnatal growth.

Purpose of the Study:

  • To investigate the role of HP1BP3 in maternal care and anxiety-related behaviors.
  • To determine the impact of HP1BP3 deficiency on pup survival and maternal retrieval.
  • To explore the neural and behavioral consequences of targeted HP1BP3 deletion in mice.

Main Methods:

  • Generation of mice with targeted deletion of HP1BP3 (Hp1bp3(-/-)).
  • Assessment of pup survival rates and co-fostering experiments.
  • Behavioral testing including pup retrieval, open-field, and elevated-plus-maze tests.
  • Evaluation of social behavior, depression, motor coordination, and olfactory capabilities.

Main Results:

  • Hp1bp3(-/-) dams exhibited a significant reduction in pup survival, which was rescued by co-fostering.
  • Hp1bp3(-/-) females failed to retrieve their own and foster pups.
  • These dams displayed reduced anxiety-like behavior but intact social behavior, depression, motor coordination, and olfactory capabilities.

Conclusions:

  • HP1BP3 plays a critical, previously unrecognized role in regulating maternal behavior and anxiety in mice.
  • HP1BP3 deficiency specifically impairs maternal care and pup retrieval without affecting other key behaviors.
  • Further research into manipulating HP1BP3-mediated epigenetic processes could offer new therapeutic avenues.