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Published on: February 9, 2019
Chitosan/lecithin liposomal nanovesicles as an oral insulin delivery system
Mayyas Al-Remawi1, Amani Elsayed2, Ibrahim Maghrabi3
1a Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences , Petra University , Amman , Jordan.
Abstract:
In the present work, insulin-chitosan polyelectrolyte complexes associated to lecithin liposomes were investigated as a new carrier for oral delivery of insulin. The preparation was characterized in terms of particle size, zeta potential and encapsulation efficiency. Surface tension measurements revealed that insulin-chitosan polyelectrolyte complexes have some degree of hydrophobicity and should be added to lecithin liposomal dispersion and not the vice versa to prevent their adsorption on the surface. Stability of insulin was enhanced when it was associated to liposomes. Significant reduction of blood glucose levels was noticed after oral administration of liposomal preparation to streptozotocin diabetic rats compared to control. The hypoglycemic activity was more prolonged compared to subcutaneously administered insulin.
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