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Updated: Mar 17, 2026

Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation
Published on: January 6, 2016
The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
1Departments of Molecular Pharmacology and Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A. jonathan.backer@einstein.yu.edu.
Abstract:
The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.
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